Inherited Cardiovascular Gene Panel

✅ Who should undergo the test

Recommended if ANY of the following apply:

1.Personal history of cardiac disease

• Cardiomyopathy (hypertrophic, dilated, restrictive)
• Primary arrhythmia syndromes (long QT, Brugada, catecholaminergic polymorphic VT, etc.)
• Unexplained sudden cardiac arrest or recurrent syncope of suspected genetic origin
• Familial Hypercholesterolemia suspicion – LDL-C ≥190 mg/dL in adults (≥160 mg/dL in children) plus family history of premature coronary disease or xanthomas

***AND one or more of the following:

• First-degree relative with premature coronary artery disease (men <55, women <65)
• First-degree relative with LDL-C above these cutoffs
• Presence of tendon xanthomas or corneal arcus before age 45

2.Strong family history of heart disease or sudden death

• One or more first-degree relatives with cardiomyopathy, arrhythmia, or sudden unexplained death (especially <50 years)
• Multiple relatives across generations with similar cardiac conditions

3.Unexplained structural or conduction abnormalities

• Early-onset AV block, unexplained cardiomegaly, or other congenital structural heart disease with suspected genetic cause.

4.Positive or suspicious family gene test

• Known pathogenic or likely pathogenic variant in a cardiac gene (e.g., MYH7, LMNA, SCN5A).

5.Pre-conception or prenatal planning in high-risk families

• Couple with a family history of inherited cardiomyopathy/arrhythmia seeking risk assessment.